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| Judith A. Neubauer |
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Division of Pulmonary & Critical Care Medicine |
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One Robert Wood Johnson Place New Brunswick, NJ 08903 |
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732 235-8961 |
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neubauer@umdnj.edu
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| Studies determining mechanisms involved in modulation of hypoxic chemosensitivity are important for understanding changes in ventilatory control and sympathetic activity associated with conditions resulting in chronic sustained and intermittent hypoxia such as Obstructive Sleep Apnea. Chronic hypoxia (CH) and chronic intermittent hypoxia (CIH) result in changes in sympathetic and respiratory responses to acute hypoxia which we propose arise because of adaptations in the hypoxic sensitivity of the C1 sympathoexcitatory and the pre-Bötzinger complex (pre-BötC) located in the rostral ventrolateral medulla (RVLM). These two regions have been shown to be sensitive to hypoxia increasing sympathetic activity or producing sighs and gasps in response to local hypoxia. Our work has established that this hypoxic sensitivity is dependent on the activity of the oxygen sensing enzyme heme oxygenase (HO). The induction of HO-1 closely corresponds to the restoration of the sympathetic and sigh responses to prolonged exposure to hypoxia. We are interested in understanding the mechanisms controlling the induction of HO-1 in these RVLM regions and how HO regulates respiratory and sympathetic responses through changes in their sensitivity brain hypoxia.
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Recent Papers:
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Dr. Neubauer`s PubMed
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BME Graduate Alumni PhD Student Wins SoE Award
May 14, 2013
PhD alumni Dr. Shirley Masand is one of 3 who has been awarded the SoE Outstanding Student Award. The award will be given to outstanding Ph.D. students in engineering graduate programs at Rutgers....
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BME-UMDNJ Researchers Test Potentially Lifesaving Tool for Detecting Schizophrenia
May 10, 2013
Thomas Papathomas, a professor in the Department of Biomedical Engineering and director of the university's Laboratory for Vision Research, and his colleague Prof. Steven Silverstein from UMDNJ...
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BME Student wins 2013 Aresty Best Poster Award
May 06, 2013
BME junior Srivathsan Babu Prabu won the best poster award for STEM (Science, Technology, Engineering, and Mathematics) fields for his poster entitled, "A Novel Method to Quantify Levels of Macrosteatosis...
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BME Faculty wins grant from NJCBIR
May 02, 2013
Professor William Craelius has been awarded a $539K, 3 year grant from the New Jersey Commission on Brain Injury Research (NJCBIR) to study , "Continuous monitoring of hemodynamic autoregulatory...
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