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Frederick H. Silver
Address: Department of Pathology and Laboratory Medicine
  675 Hoes Lane, Piscataway, NJ 08854
Room: R204
Phone:
Email: fhsilver AT hotmail.com
 
Biomaterials, Biomechanics, Mechanotransduction and Medical Devices Extracellular matrix (ECM) is found in both vertebrates and invertebrates and forms the structural scaffold of all tissues and organs. The components of ECM include collagen fibers, proteoglycans, elastic fibers and cells. My laboratory is interested in understanding how these components are assembled into multifunctional tissues that allow mammals to locomote, heal when wounded and store energy through mechanotransduction. Our studies focus on the relationship between structure and properties of ECMs and the use of tissue engineered ECMs as implants. We are also interested in changes in mechanotransduction with age that may lead to impaired healing and disease.
Recent Papers:

1.   Landis, W.J., and Silver, F.H. 2009. Mineral deposition in the extracellular matrices of vertebrate tissues: identification of possible apatite nucleation sites on type I collagen. Cells Tissues Organs. 2009;189(1-4):20-4.

2.   Seehra, G.P., and Silver, F.H. 2006. Viscoelastic properties of acid- and alkaline-treated human dermis: a correlation between total surface charge and elastic modulus. Skin Res Technol. 2006 Aug;12(3):190-8.

3.   Freeman, J.W., and Silver, F.H. 2005. The effects of prestrain and collagen fibril alignment on in vitro mineralization of self-assembled collagen fibers. Connect Tissue Res. 2005;46(2):107-15.

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