Charles M. Roth Address: 98 Brett Road, Piscataway, NJ 08854 Room: C257, Engineering, Busch Campus Phone: 732-445-4109 Email: cmroth@rci.rutgers.edu   Our work involves the development of gene-based probes and therapeutics and applying these entities to functional genomics, inflammatory diseases and tissue engineering. We have developed a rational design algorithm for selecting antisense oligonucleotide inhibitors of gene expression. We are using these inhibitors to modulate integrated molecular systems, such as (1) transcription factors controlling the growth vs. differentiation of hepatocytes and (2) signal transduction pathways controlling the pro- vs. anti-inflammatory properties of corticosteroids.

Recent Papers: 1.   Lee LK and Roth CM, “Antisense Technology in Molecular and Cellular Bioengineering” Curr. Opin. Biotechnol. (in press). 2.   Roth CM, “Quantifying Gene Expression” Curr. Issues Mol. Biol. 4:93-100 (2002). 3.   Walton SP, Stephanopoulos GN, Yarmush ML, Roth CM, “Thermodynamics and Kinetics of Antisense Oligonucleotide Binding” Biophys. J 82:366-377 (2002).