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Charalampos (Babis) Kalodimos
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| Address: |
599 Taylor Road |
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Piscataway, NJ 08854 |
| Room: |
209 |
| Phone: |
732-445-4500 x6209 |
| Email: |
babis@rci.rutgers.edu |
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| The main research interests of the lab have been focused on the elucidation of the molecular and mechanistic basis of a wide range of important biological phenomena. Our current and future efforts are directed towards understanding how central biological processes, such as transcription regulation, protein translocation and secretion, cell signaling, and protein folding take place. A detailed characterization of biomolecular interactions necessarily involves investigation of the inter-relationship between function, structure, dynamics, kinetics and energetics of a system. Towards this challenging goal, we employ state-of-the-art NMR spectroscopy methodologies complemented by many other biochemical and biophysical techniques. NMR spectroscopy in particular is a very powerful methodology that allows the study of the three-dimensional structure of biomolecules in semi-physiological conditions. Furthermore, NMR spectroscopy can provide a unique insight into the dynamic aspects of the macromolecules and their interaction with ligands over time. |
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Recent Papers:
1. Gelis I, Bonvin A, Keramisanou D, Economou A. Kalodimos CG (2007) Structural basis for signal sequence recognition by the 204-kDa translocase motor SecA determined by NMR. Cell. 131:756-769.
2. Sarkar P, Reichman C, Saleh T, Birge RB, C.G. Kalodimos CG (2007) Proline cis-trans isomerization controls autoinhibition of a signaling protein. Molecular Cell. 25: 413-426.
3. Popovych N, Sun S, Ebright RH, Kalodimos CG (2006) Dynamically driven protein allosteric cooperativity. Nature Structural & Molecular Biology. 13: 831-838.
Lab web site
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Congratulations to Professor Ki-Bum Lee, Graduate Faculty in BME & Stem Cell IGERT Faculty, for bagging the highly competitive NIH Director's New Innovator award, given nationally to a small number...
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