Ioannis (Yannis) P. Androulakis

Professor, Undergraduate Director

Biomedical Engineering

Office Hours: By appointment
Website: Ioannis (Yannis) P. Androulakis

Dr. Androulakis received his B.S. in Chemical Engineering from the National Technical University of Athens, Greece, and he subsequently obtained his M.S and Ph.D. from Purdue University. He spent two years at Princeton University as a research associate before joining ExxonMobil's Corporate Strategic Research Laboratories, where he eventually became the Informatics and Knowledge Capitalization technical project leader before joining the Departments of Biomedical Engineering and Chemical & Biochemical Engineering at Rutgers University. His work has been funded by the US Environmental Protection Agency, the National Science Foundation, the Office of Naval Research, and the National Institutes of Health.


Post-doctoral Fellow, Princeton University, 1993-1996
Ph.D. Chemical Engineering, Purdue University, 1993
M.S., Chemical Engineering, Purdue University, 1990
B.S., Chemical Engineering, National Technical University of Athens, 1988


  • 2005, 2006, 2007, 2008, 2009, 2010, 2011 - Rutgers FASIP Award for Teaching, Research, and Service
  • 2006 - Excellence in Teaching Award, Engineering Governing Council, School of Engineering, Rutgers University
  • 2004 - Outstanding contributed paper, Foundations of Computer-Aided Process Design: Discovery through Product and Process Design, Princeton, NJ
  • Catalytic partial oxidation using staged oxygen addition (US Pat. No. 6,726,850)

Professional Affiliations

  • American Institute of Chemical Engineers
  • Society for Complexity in Acute Illness
  • International Society of Translational Medicine
  • Biomedical Engineering Society
  • Society of Biological Engineers 

Research Interests

Dr. Androulakis actively pursues research activities in the area of Systems Biology, loosely defined as an integrative modeling and experimental framework that approaches biological entities as "systems" in the physical and engineering sense. Of particular interest are issues related to "functional physiomics" in an attempt to establish functional links between cellular events, such as signaling, transcription and translation, and an expanding envelope of interactions which include the bidirectional links between cells, tissues, organs, environmental signals and physiological responses. The ultimate goal is to develop in silico methodologies that will enable translational research by elucidating putative mechanisms by which macroscopic responses, at the physiome level, can be functionally modulated through mechanistic interventions. Of particular importance are the opportunities of such an integrative approach applied to the inflammatory responses due to the critical role inflammation plays in a number of physiologically and clinically relevant situations. His work integrates a compendium of experimental systems, from cell cultures, to animal models, to human studies in order to address different questions at their appropriate level of detail.

Selected Publications

1. Kamisoglu, K., J.S. Mattick and I.P. Androulakis, Topology and dynamics of signaling networks: In search of transcriptional control of the inflammatory response, Ann. Rev. Biomedical Eng., vol 15 (2013)
2. Stamatelos, S.K., I.P. Androulakis, A-N Kong and P.G. Georgopoulos, An integrated semimechanistic toxicokinetic-toxicodynamic (TD/TK) model for arsenic(III) exposure in hepatocytes, J. Theo. Biol., 317C_244-256 (2012)
3. Wang, H., T.O. Khor, Q. Yang, T.Y. Wu, C.L. Saw, W. Lin, I.P. Androulakis and A.N. Kong, Pharmacokinetics and Pharmacodynamics of Phase II Drug Metabolizing/Antioxidant Enzymes Gene Response by Anti-cancer Agent Sulforaphane in Rat Lymphocytes, Mol Pharm., 9(10):2819- 27 (2012)
4. Androulakis, IP, Preface: Dr. Stephen F. Lowry, Crit. Rev. Biomedical Eng., 40(4):259-260 (2012)
5. Sunderram, J. and I.P. Androulakis, Molecular mechanisms of chronic intermittent hypoxia induced hypertension, Crit. Rev. Biomedical Eng., 40(4):265-278 (2012)
6. Foteinou, P.T., P. Mavroudis, J.D. Scheff, S.E. Calvano and I.P. Androulakis, Modeling systemic inflammation Challenges and Opportunities, Crit. Rev. Biomedical Eng., 40(4):313-322 (2012)
7. Mattick, J.S., Q. Yang, M.A. Orman, M.G. Ierapetritou, F. Berhtiaume and I.P. Androulakis, Longterm gene expression profile dynamics following cecal ligation and puncture in the rat, J. Surg. Res., 178(1):431-442 (2012)
8. Dick, T.E., Y. Molkov, G. Niemam, Y-H. Hsieh, F.J. Jacono, H. Doyle, S.D. Scheff, S.E. Calvano, I.P. Androulakis and Y. Vodovotz, Linking Inflammation and Cardiorespiratory Variability in Sepsis via Computational Modeling, Front. Physiol.,3:222 (2012)
9. He, K., M.G. Ierapetritou and I.P. Androulakis, Exploring flux representations of complex kinetics networks , AIChE J, 58(2):533(2012)
10. Yang, Q., J.S. Mattick, M.A. Orman, T.T. Nguyen, M.G. Ierapetritou, F. Berthiaume and I.P. Androulakis, Dynamics of hepatic gene expression profile in a rat cecal ligation and puncture model J. Surg. Res., 176(2):583-600 (2012)
11. Yang, Q., M.A. Orman, M.G. Ierapetritou, F. Berthiaume and I.P. Androulakis, Dynamics of shorttem gene expression profiling in liver following thermal injury, J. Surg. Res., 176(2):549-558 (2012)
12. Mavroudis, P., J.D. Scheff, S.E. Calvano, S.F. Lowry and I.P. Androulakis, Entrainmenet of peripheral clock genes by cortisol, Phys. Genomics, 144(11):607 (2012)
13. Namas, R., R. Zamora, R. Namas, G. An, J. Doyle, T.E. Dick, F.J. Jacono, I.P. Androulakis, G.F. Nieman, S. Chang, T.R. Billiar, J.A. Kellum, D. C. Angus and Y. Vodovotz, Sepsis: Something old, something new and a systems view, J. Crit. Care, 27:314 (2012)
14. Orman, M.A, M.G. Ierapetritou, F. Berthiaume and I.P. Androulakis, Long-term dynamics profling of inflammatory mediators in double-hit burn and sepsis animal models, Cytokine, 58(2):307-315 (2012)