Professor Charles Roth and collaborators at Daemen College and the U.S. Army Institute of Surgical Research have received a $500,000 contract from the Department of Defense for their proposal entitled "Integrated Proteomic Analysis and siRNA Therapy for Treatment of Heterotopic Ossification." The goal of this project is to identify molecular triggers for heterotopic ossification (bone growth in soft tissue; a major cause of morbidity following blast injury) using proteomic analysis of clinical samples and to silence the corresponding genes using siRNA delivered locally in a nanoparticle formulation.