In the September 23, 2004 issue of the journal �Nature�, Profs. Troy Shinbrot and Ben Glasser demonstrate that stirring a mixture of granular materials faster or longer won�t always generate a smooth blend. In fact, ingredients that were thought to be thoroughly mixed may have actually separated. The consequences of these findings are quite widespread, and very crucial in the context of pharmaceutical manufacturing where pills might not have an effective amount of active agent due to mixing induced anomalies.